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Growth suppression of colorectal cancer expressing S492R EGFR by monoclonal antibody CH12

Qiongna Dong, Bizhi Shi, Min Zhou, Huiping Gao, Xiaoying Luo, Zonghai Li, Hua Jiang

《医学前沿（英文）》 2019年 第13卷 第1期   页码 83-93 doi: 10.1007/s11684-019-0682-z

摘要：

Colorectal cancer (CRC) is a common malignant tumor in the digestive tract, and 30%–85% of CRCs express epidermal growth factor receptors (EGFRs). Recently, treatments using cetuximab, also named C225, an anti-EGFR monoclonal antibody, for CRC have been demonstrated to cause an S492R mutation in EGFR. However, little is known about the biological function of S492R EGFR. Therefore, we attempted to elucidate its biological function in CRC cells and explore new treatment strategies for this mutant form. Our study indicated that EGFR and S492R EGFR accelerate the growth of CRC cells in vitro and in vivo and monoclonal antibody CH12, which specifically recognizes an EGFR tumor-specific epitope, can bind efficiently to S492R EGFR. Furthermore, mAb CH12 showed significantly stronger growth suppression activities and induced a more potent antibody-dependent cellular cytotoxicity effect on CRC cells bearing S492R EGFR than mAb C225. mAb CH12 obviously suppressed the growth of CRC xenografts with S492R EGFR mutations in vivo. Thus, mAb CH12 may be a promising therapeutic agent in treating patients with CRC bearing an S492R EGFR mutation.

关键词： S492R EGFR ectodomain mutation     colorectal cancer     mAb CH12     immunnotherapy    

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The catalytic effect of both oxygen-bearing functional group and ash in carbonaceous catalyst on CH 4

Weidong ZHANG, Yongfa ZHANG,

《化学科学与工程前沿（英文）》 2010年 第4卷 第2期   页码 147-152 doi: 10.1007/s11705-009-0242-1

摘要： A kind of new catalyst—carbonaceous catalyst—for CH-CO reformation has been developed in our laboratory. The effect of both oxygen-bearing functional group such as phenolic hydroxyl, carbonyl, carboxyl, and lactonic, and ash such as FeO, NaCO, and KCO in the carbonaceous catalyst on the CH-CO reforming has been investigated with a fixed-bed reactor. It has been found that the carbonaceous catalyst is an efficient catalyst on CO-CH reforming. With the decrease of oxygen-bearing functional group, the catalytic activity of carbonaceous catalyst decreases quickly. The oxygen-bearing functional groups play a significant role in the carbonaceous-catalyzed CO-CH reforming; the ash components in carbonaceous catalyst also have an important influence on the CO-CH reforming. FeO, NaCO, and KCO in the ash can catalyze the CO-CH reforming reaction; CaO has little effect on CO-CH reforming reaction. CaO can catalyze the gasification between carbonaceous catalyst and CO; AlO and MgO inhibit the CO-CH reforming.

关键词： oxygen-bearing functional     carboxyl     phenolic hydroxyl     CH-CO reformation     CO-CH reforming    

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Advances of 12th CAPS research symposium: young chemists and chemical engineers fronts

Guoping Hu, Baiqian Dai

《化学科学与工程前沿（英文）》 2021年 第15卷 第3期   页码 461-463 doi: 10.1007/s11705-020-2026-6

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Introduction to the special section on the 12

Zhen-Min CHENG

《化学科学与工程前沿（英文）》 2009年 第3卷 第1期   页码 1-1 doi: 10.1007/s11705-009-0003-1

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Artificial intelligence in gastroenterology: where are we heading?

Joseph JY Sung, Nicholas CH Poon

《医学前沿（英文）》 2020年 第14卷 第4期   页码 511-517 doi: 10.1007/s11684-020-0742-4

摘要： Artificial intelligence (AI) is coming to medicine in a big wave. From making diagnosis in various medical conditions, following the latest advancements in scientific literature, suggesting appropriate therapies, to predicting prognosis and outcome of diseases and conditions, AI is offering unprecedented possibilities to improve care for patients. Gastroenterology is a field that AI can make a significant impact. This is partly because the diagnosis of gastrointestinal conditions relies a lot on image-based investigations and procedures (endoscopy and radiology). AI-assisted image analysis can make accurate assessment and provide more information than conventional analysis. AI integration of genomic, epigenetic, and metagenomic data may offer new classifications of gastrointestinal cancers and suggest optimal personalized treatments. In managing relapsing and remitting diseases such as inflammatory bowel disease, irritable bowel syndrome, and peptic ulcer bleeding, convoluted neural network may formulate models to predict disease outcome, enhancing treatment efficacy. AI and surgical robots can also assist surgeons in conducting gastrointestinal operations. While the advancement and new opportunities are exciting, the responsibility and liability issues of AI-assisted diagnosis and management need much deliberations.

关键词： artificial intelligence     endoscopy     robotics     gastrointestinal diseases    

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Online gasoline blending with EPA Complex Model for predicting emissions

Stefan JANAQI, Mériam CHÈBRE, Guillaume PITOLLAT

《工程管理前沿（英文）》 2018年 第5卷 第2期   页码 214-226 doi: 10.15302/J-FEM-2017022

摘要： The empirical Complex Model developed by the US Environmental Protection Agency (EPA) is used by refiners to predict the toxic emissions of reformulated gasoline with respect to gasoline properties. The difficulty in implementing this model in the blending process stems from the implicit definition of Complex Model through a series of disjunctions assembled by the EPA in the form of spreadsheets. A major breakthrough in the refinery-based Complex Model implementation occurred in 2008 and 2010 through the use of generalized disjunctive and mixed-integer nonlinear programming (MINLP). Nevertheless, the execution time of these MINLP models remains prohibitively long to control emissions with our online gasoline blender. The first objective of this study is to present a new model that decreases the execution time of our online controller. The second objective is to consider toxic thresholds as hard constraints to be verified and search for blends that verify them. Our approach introduces a new way to write the Complex Model without any binary or integer variables. Sigmoid functions are used herein to approximate step functions until the measurement precision for each blend property is reached. By knowing this level of precision, we are able to propose an extremely good and differentiable approximation of the Complex Model. Next, a differentiable objective function is introduced to penalize emission values higher than the threshold emissions. Our optimization module has been implemented and tested with real data. The execution time never exceeded 1 s, which allows the online regulation of emissions the same way as other traditional properties of blended gasoline.

关键词： emissions     reformulated gasoline     online control     global optimization    

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ThMn12型永磁合金 Review

G.C. Hadjipanayis, A.M. Gabay, A.M. Schönhöbel, A. Martín-Cid, J.M. Barandiaran, D. Niarchos

《工程（英文）》 2020年 第6卷 第2期   页码 140-146 doi: 10.1016/j.eng.2018.12.011

摘要：

具有四方ThMn12型结构的富铁化合物有潜力满足当下人们对于高磁能积、工作温度为150~200 ℃的贫稀土永磁体的需求。尽管磁体制备技术的发展滞后于相关磁性材料的研究是正常的，但对于ThMn12型磁性材料而言，这种研究进展的差异非常显著。人们发现，引入镧（La）可以提高Sm(Fe,Ti)12中少数低熔点相的稳定性，从而首次使得液相烧结成为可能。然而，La金属的高反应活性会明显地破坏材料的矫顽力（Hc）。,Sm)(Fe,Ti)12合金中也可以实现。机械化学合成的(Sm,Zr)(Fe,Si)12和(Sm,Zr)(Fe,Co,Ti)12粉末可能适合烧结成具有高强度的全致密磁体，尽管在此之前，两者都已开发出较高的各向异性

关键词： 永磁体，稀土永磁体，ThMn 12 结构    

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Major bridge development in Hong Kong, China—past, present and future

Michael CH HUI, Doris YAU

《结构与土木工程前沿（英文）》 2011年 第5卷 第4期   页码 405-414 doi: 10.1007/s11709-011-0136-4

摘要： The first “modern” type of vehicular bridge was built in Hong Kong China in the 1920s. The need for an efficient transportation system to cope with population growth and enable economic development has demanded the construction of more and more bridges since the middle of the 20th century. By 2007, Hong Kong had a total of about 1300 vehicular bridges. Four of these bridges, including the Tsing Ma Bridge, Kap Shui Mun Bridge, Ting Kau Bridge, and the cable-stayed bridge on the Hong Kong- Shenzhen Western Corridor, are considered to be major bridges supported by cables. Currently, the Stonecutters Bridge on Route No. 8 is under construction and is expected to be completed in late 2009. At the same time, the Hong Kong-Zhuhai-Macao Bridge will be in its detailed design stage soon. While efforts have been made by bridge builders to construct these giant structures, the upkeeping of these valuable assets at a high standard and ensuring their continuous functioning and performance during their intended lifespans will be another important task for bridge engineers. Wind and structural health monitoring system (WASHMS) will play a key role in this respect.

关键词： Tsing Ma Bridge     Kap Shui Mun Bridge     Ting Kau Bridge     Stonecutters Bridge     Hong Kong-Zhuhai-Macao Bridge     wind and structural health monitoring system (WASHMS)    

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Proposed EU legislation to force changes in sewage sludge disposal: A case study

Vojtěch Turek, Bohuslav Kilkovský, Zdeněk Jegla, Petr Stehlík

《化学科学与工程前沿（英文）》 2018年 第12卷 第4期   页码 660-669 doi: 10.1007/s11705-018-1773-0

摘要：

The consequences of changes planned in the European Union legislation relevant to the disposal of sewage sludges are discussed. A specific municipal waste water treatment plant is analyzed in terms of drying and subsequent combustion or pyrolysis of the produced stabilized sludge, and the respective net energy balances are carried out. A simplified economic analysis of the two disposal options is presented, which suggest that combustion of the sludge would be economically infeasible while pyrolysis of the sludge in a modular, self-sufficient container unit can bring a small financial benefit due to the selling of the produced phosphorus-rich biochar.

关键词： sewage sludge     drying     combustion     pyrolysis    

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我国半导体硅片发展现状与展望

张果虎,肖清华,马飞

《中国工程科学》 2023年 第25卷 第1期   页码 68-78 doi: 10.15302/J-SSCAE-2023.01.002

摘要： 本文重点围绕市场主流的8 in、12 in硅片，分析了全球半导体硅片的技术和产业发展现状，研判了全球半导体硅片产业未来的发展趋势，重点分析了我国半导体硅片的发展现状，指出我国半导体硅片在当前市场需求、宏观政策

关键词： 半导体硅片；8 in；12 in；产业协同；先进制程    

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Facile controlled synthesis of hierarchically structured mesoporous Li4Ti5O12/C/rGO composites as high-performance

Cehuang FU, Shuiyun SHEN, Ruofei WU, Xiaohui YAN, Guofeng XIA, Junliang ZHANG

《能源前沿（英文）》 2022年 第16卷 第4期   页码 607-612 doi: 10.1007/s11708-021-0798-0

摘要： In this paper, a facile strategy is proposed to controllably synthesize mesoporous Li4Ti5O12/C nanocomposite embedded in graphene matrix as lithium-ion battery anode via the co-assembly of Li4Ti5O12 (LTO) precursor, GO, and phenolic resin. The obtained composites, which consists of a LTO core, a phenolic-resin-based carbon shell, and a porous frame constructed by rGO, can be denoted as LTO/C/rGO and presents a hierarchical structure. Owing to the advantages of the hierarchical structure, including a high surface area and a high electric conductivity, the mesoporous LTO/C/rGO composite exhibits a greatly improved rate capability as the anode material in contrast to the conventional LTO electrode.

关键词： Li4Ti5O12     phenolic-resin-based carbon     mesoporous composite     graphene    

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Poor adherence to P2Y12 antagonists increased cardiovascular risks in Chinese PCI-treated patients

null

《医学前沿（英文）》 2017年 第11卷 第1期   页码 53-61 doi: 10.1007/s11684-017-0502-2

摘要：

Low adherence to secondary prevention medications (ATM) of patients after acute coronary syndrome (ACS) is associated with poor clinical outcomes. However, literature provides limited data on assessment of ATM and risks associated with poor in Chinese patients with ACS. In the current work, ATM was assessed in consecutively recruited patients with ACS in Tongji Hospital from November 5, 2013 to December 31, 2014. A total of 2126 patients were classified under low adherence (proportion of days covered (PDC)<50%) and high adherence (PDC>50%) groups based on their performance after discharge. All patients were followed up at the 1st, 6th, and 12th month of discharge while recording ATM and major adverse cardiac events (MACE). Bivariate logistic regression was used to identify the factors associated with ATM. Cox regression was used to analyze the association between ATM and MACE within one year after discharge. Results showed that coronary artery bypass grafting (CABG) alone had significantly lower proportion of high adherence to P2Y12 antagonists (83.0% vs. 90.7%, P<0.01) than patients treated with percutaneous coronary intervention (PCI) only. Moreover, in patients undergoing PCI, high adherence to P2Y12 antagonists decreased the risk of MACE (hazard ratio=0.172, 95% confidence interval: 0.039–0.763; P=0.021). In conclusion, PCI-treated patients are more prone to remaining adherent to medications than CABG-treated patients. High adherence to P2Y12 antagonists was associated with lower risk of MACE.

关键词： acute coronary syndromes     adherence to secondary prevention medications     clinical outcome    

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交直流电力集成技术

马伟明

《中国工程科学》 2002年 第4卷 第12期   页码 53-59

摘要： 在此基础上，将定子3相绕组、12相绕组、整流装置、励磁系统、励磁调节器等集于一体，功研制出性能优良的交直流发电机，能同时提供高品质交直流电源，为独立电力系统的集成化奠定了基础。

关键词： 电力集成     双绕组交直流发电机     12相整流     交直流同时供电     独立电力系统    

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利用基因组特异性引物和Cas12a介导技术快速检测稻瘟菌小麦致病型 Article

康厚祥, 彭烨, Kangyu Hua, 邓雨飞, Maria Bellizzi, Dipali Rani Gupta, Nur Uddin Mahmud, Alfredo S. Urashima, Sanjoy Kumar Paul, Gary Peterson, 周益林, 周雪平, Md Tofazzal Islam, 王国梁

《工程（英文）》 2021年 第7卷 第9期   页码 1326-1335 doi: 10.1016/j.eng.2020.07.016

摘要： 随后，我们使用Cas12a 蛋白及导向RNA（gRNA）靶向MoT-6098 和MoT-6099 序列，两个靶标被识别后，均能激活Cas12a 非特异切割单链脱氧核糖核酸酶（ssDNAase）的活性，我们将依赖靶向Cas12a 激活ssDNase 活性，同时将重组酶聚合酶扩增（RPA）和核酸侧流免疫分析法（NALFIA）相结合，开发出一种准确、灵敏且经济高效地检测受感染小麦植株中

关键词： 麦瘟病     稻瘟菌小麦致病型     Cas12a     核酸侧流免疫分析     田间检测    

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Real time monitoring of bioreactor mAb IgG3 cell culture process dynamics via Fourier transform infrared

Huiquan Wu, Erik Read, Maury White, Brittany Chavez, Kurt Brorson, Cyrus Agarabi, Mansoor Khan

《化学科学与工程前沿（英文）》 2015年 第9卷 第3期   页码 386-406 doi: 10.1007/s11705-015-1533-3

摘要： Compared to small molecule process analytical technology (PAT) applications, biotechnology product PAT applications have certain unique challenges and opportunities. Understanding process dynamics of bioreactor cell culture process is essential to establish an appropriate process control strategy for biotechnology product PAT applications. Inline spectroscopic techniques for real time monitoring of bioreactor cell culture process have the distinct potential to develop PAT approaches in manufacturing biotechnology drug products. However, the use of inline Fourier transform infrared (FTIR) spectroscopic techniques for bioreactor cell culture process monitoring has not been reported. In this work, real time inline FTIR Spectroscopy was applied to a lab scale bioreactor mAb IgG3 cell culture fluid biomolecular dynamic model. The technical feasibility of using FTIR Spectroscopy for real time tracking and monitoring four key cell culture metabolites (including glucose, glutamine, lactate, and ammonia) and protein yield at increasing levels of complexity (simple binary system, fully formulated media, actual bioreactor cell culture process) was evaluated via a stepwise approach. The FTIR fingerprints of the key metabolites were identified. The multivariate partial least squares (PLS) calibration models were established to correlate the process FTIR spectra with the concentrations of key metabolites and protein yield of in-process samples, either individually for each metabolite and protein or globally for all four metabolites simultaneously. Applying the 2 derivative pre-processing algorithm to the FTIR spectra helps to reduce the number of PLS latent variables needed significantly and thus simplify the interpretation of the PLS models. The validated PLS models show promise in predicting the concentration profiles of glucose, glutamine, lactate, and ammonia and protein yield over the course of the bioreactor cell culture process. Therefore, this work demonstrated the technical feasibility of real time monitoring of the bioreactor cell culture process via FTIR spectroscopy. Its implications for enabling cell culture PAT were discussed.

关键词： process analytical technology (PAT)     Fourier-transform infrared (FTIR) spectroscopy     partial least squares (PLS) regression     mouse IgG3     bioreactor cell culture process     real time process monitoring    

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标题 作者 时间 类型 操作

Growth suppression of colorectal cancer expressing S492R EGFR by monoclonal antibody CH12

Qiongna Dong, Bizhi Shi, Min Zhou, Huiping Gao, Xiaoying Luo, Zonghai Li, Hua Jiang

期刊论文

The catalytic effect of both oxygen-bearing functional group and ash in carbonaceous catalyst on CH 4

Weidong ZHANG, Yongfa ZHANG,

期刊论文

Advances of 12th CAPS research symposium: young chemists and chemical engineers fronts

Guoping Hu, Baiqian Dai

期刊论文

Introduction to the special section on the 12

Zhen-Min CHENG

期刊论文

Artificial intelligence in gastroenterology: where are we heading?

Joseph JY Sung, Nicholas CH Poon

期刊论文

Online gasoline blending with EPA Complex Model for predicting emissions

Stefan JANAQI, Mériam CHÈBRE, Guillaume PITOLLAT

期刊论文

ThMn12型永磁合金

G.C. Hadjipanayis, A.M. Gabay, A.M. Schönhöbel, A. Martín-Cid, J.M. Barandiaran, D. Niarchos

期刊论文

Major bridge development in Hong Kong, China—past, present and future

Michael CH HUI, Doris YAU

期刊论文

Proposed EU legislation to force changes in sewage sludge disposal: A case study

Vojtěch Turek, Bohuslav Kilkovský, Zdeněk Jegla, Petr Stehlík

期刊论文

我国半导体硅片发展现状与展望

张果虎,肖清华,马飞

期刊论文

Facile controlled synthesis of hierarchically structured mesoporous Li4Ti5O12/C/rGO composites as high-performance

Cehuang FU, Shuiyun SHEN, Ruofei WU, Xiaohui YAN, Guofeng XIA, Junliang ZHANG

期刊论文

Poor adherence to P2Y12 antagonists increased cardiovascular risks in Chinese PCI-treated patients

null

期刊论文

交直流电力集成技术

马伟明

期刊论文

利用基因组特异性引物和Cas12a介导技术快速检测稻瘟菌小麦致病型

康厚祥, 彭烨, Kangyu Hua, 邓雨飞, Maria Bellizzi, Dipali Rani Gupta, Nur Uddin Mahmud, Alfredo S. Urashima, Sanjoy Kumar Paul, Gary Peterson, 周益林, 周雪平, Md Tofazzal Islam, 王国梁

期刊论文

Real time monitoring of bioreactor mAb IgG3 cell culture process dynamics via Fourier transform infrared

Huiquan Wu, Erik Read, Maury White, Brittany Chavez, Kurt Brorson, Cyrus Agarabi, Mansoor Khan

期刊论文